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PMID: 31178587
Free PMC article.
High-resolution ternary complex crystal structures and biophysical investigation guided rational and efficient optimization toward ACBI1, a potent and cooperative degrader of SMARCA2, SMARCA4 and PBRM1. ACBI1 induced anti-proliferative effects and cell death caused by SMAR …
High-resolution ternary complex crystal structures and biophysical investigation guided rational and efficient optimization toward ACBI1, a …